Technical background & Resources
This page will provide access to the various resources such as publications, posters and flyers. You can also find information about the background for the development of ToxTracker.
Technical background & rationale for development
Interaction of newly developed materials, chemicals and drugs with biomolecules may disrupt cellular homeostasis and can ultimately lead to severe tissue damage or induction of cancer. Inflicted cellular damage is recognized by specialized sensor proteins that trigger a complex network of cellular signaling pathways resulting in activation or inactivation of specific enzymes and altered expression of distinct gene networks. Therefore, visualisation of damage specific cellular stress response pathways that are activated upon exposure to chemicals or xenobiotics provides insight into the type and extent of cellular damage that has been induced and thus the biological (re)activity of compounds. ToxTracker is based on visualising specific damage response pathways.